Rao Lab
Translational Hematopoiesis and Post-Transcriptional Gene Regulation
Post-Transcriptional Gene Regulation in Hematopoietic Development and Cancer
The control of hematopoietic differentiation and its dysregulation in leukemia is complex- and many newly discovered elements of gene expression regulation play important roles.
We have recently made some important inroads into microRNA- and long non-coding RNA- dependent regulation of B-cell differentiation and leukemogenesis. Additionally, our research into post-transcriptional gene regulation recently became focused on RNA-binding proteins, which appear to be extremely important regulators of this unique mode of gene regulation.
Our research points to critical roles played by non-traditional modes of gene regulation in hematopoiesis and cancer. It's our goal to understand these roles and to determine how we can leverage these novel mechanisms in the diagnosis and treatment of human diseases.
About the Rao Lab
We are in the Department of Pathology and Laboratory Medicine at the David Geffen School of Medicine at UCLA. We are affiliated with the Jonsson Comprehensive Cancer Center and the Eli and Edythe Broad Stem Cell Research Center at UCLA.